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Howard Y. Chang, MD
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Howard Y. Chang, MD

Internist - General

Highlights

  • Board Certified
  • Accepts Insurance Plans

Biography

Howard Y. Chang, MD is a Internist - General practicing in Boston, MA

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Provider Training

InstitutionFocusYear
Internship - Santa Clara Valley Medical Center2001
Residency - Stanford University School of Medicine2003
Fellowship - Stanford University School of Medicine,Stanford, Ca, United States2004

CertificationCert. BodyYear
DermatologyDermatology2004

Experience & Accolades

Publication Publisher Title Published
Other PublicationNatureLandscape and variation of RNA secondary structure across the human transcriptome.2014
Other PublicationCELLHierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons2013
Other PublicationCELLLong Noncoding RNAs: Cellular Address Codes in Development and Disease2013
Other PublicationNATUREControl of somatic tissue differentiation by the long non-coding RNA TINCR2013
Other PublicationeLifeA mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.2013
Other PublicationNature methodsTransposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin2013
Other PublicationCELLAging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock2012
Other PublicationNATUREA long noncoding RNA maintains active chromatin to coordinate homeotic gene expression2011
Other PublicationCell reportsTargeted disruption of hotair leads to homeotic transformation and gene derepression.2013
Other PublicationNature protocolsGenome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing.2013
Other PublicationCURRENT OPINION IN CELL BIOLOGYCytotopic localization by long noncoding RNAs2013
Other PublicationCELLThe NeST Long ncRNA Controls Microbial Susceptibility2013
Other PublicationJOURNAL OF INVESTIGATIVE DERMATOLOGYRejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment2013
Other PublicationGENOME RESEARCHSeqFold: Genome-scale reconstruction of RNA secondary structure integrating high-throughput2013
Other PublicationNATURE CHEMICAL BIOLOGYRNA SHAPE analysis in living cells2013
Other PublicationNATURE METHODSSystematic reconstruction of RNA functional motifs with high-throughput microfluidics2012
Other PublicationBMC GENOMICSIdentification of proteins binding coding and non-coding human RNAs using protein microarrays2012
Other PublicationMOLECULAR CELLGenome-wide Measurement of RNA Folding Energies2012
Other PublicationPLOS ONEDetection of Long Non-Coding RNA in Archival Tissue2012
Other PublicationBLOODTranscriptome sequencing in Sezary syndrome identifies Sezary cell2012
Other PublicationSTEM CELLS AND DEVELOPMENTA Molecular Signature for Purified Definitive Endoderm Guides Differentiation2012
Other PublicationCANCER DISCOVERYThe Transcription Factor ZNF217 Is a Prognostic Biomarker2012
Other PublicationCURRENT OPINION IN GENETICS & DEVELOPMENTActive chromatin and noncoding RNAs: an intimate relationship2012
Other PublicationGENES & DEVELOPMENTSuppression of progenitor differentiation requires the long noncoding RNA ANCR2012
Other PublicationGENOME BIOLOGYTranscriptional profiling of long non-coding RNAs2012
Other PublicationANNUAL REVIEW OF BIOCHEMISTRY, VOL 81Genome Regulation by Long Noncoding RNAs2012
Other PublicationJournal of visualized experiments : JoVEChromatin isolation by RNA purification (ChIRP).
Other PublicationLAB ON A CHIPHigh throughput automated chromatin immunoprecipitation as a platform for drug screening2012
Other PublicationMOLECULAR CELLGenomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions2011
Other PublicationCELL STEM CELLDirect Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons2011
Other PublicationMOLECULAR CELLMolecular Mechanisms of Long Noncoding RNAs2011
Other PublicationJOURNAL OF CLINICAL INVESTIGATIONDisruption of PPAR gamma2011
Other PublicationNATURE REVIEWS GENETICSUnderstanding the transcriptome through RNA structure2011
Other PublicationEMBO REPORTSCrystal structure of the N-terminal region of human Ash2L shows a winged2011
Other PublicationNATURE GENETICSExtensive and coordinated transcription of noncoding RNAs within cell-cycle promoters2011
Other PublicationTRENDS IN CELL BIOLOGYLong noncoding RNAs and human disease2011
Other PublicationPLOS GENETICSDynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks2011
Other PublicationEPIGENETICSRNA templating the epigenome Long noncoding RNAs as molecular scaffolds2011
Other PublicationCANCER RESEARCHLong Intergenic Noncoding RNAs: New Links in Cancer Progression2011
Other PublicationCELL STEM CELLNoncoding RNA Landmarks of Pluripotency and Reprogramming2010
Other PublicationJOURNAL OF CELL BIOLOGYG1 arrest and differentiation can occur independently of Rb family function2010
Other PublicationNATUREGenome-wide measurement of RNA secondary structure in yeast2010
Other PublicationRNA BIOLOGYLong noncoding RNA in genome regulation Prospects and mechanisms2010
Other PublicationCELL CYCLEHOTAIR Flight of noncoding RNAs in cancer metastasis2010
Other PublicationSCIENCELong Noncoding RNA as Modular Scaffold of Histone Modification Complexes2010
Other PublicationCELL CYCLETumor suppression by the histone demethylase UTX2010
Other PublicationNATURELong non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis2010
Other PublicationJOURNAL OF INVESTIGATIVE DERMATOLOGYA TGF beta-Responsive Gene Signature Is Associated with a Subset of Diffuse Scleroderma with2010
Other PublicationGENES & DEVELOPMENTThe histone demethylase UTX enables RB-dependent cell fate control2010
Other PublicationSCIENCEAnatomic Demarcation of Cells: Genes to Patterns2009
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OIdentification, molecular characterization2009
Other PublicationEMBO REPORTSGene dates, parties and galas Symposium on Chromatin Dynamics and Higher Order Organization2009
Other PublicationCANCER CELLTumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis2009
Other PublicationCANCER CELLModeling Inducible Human Tissue Neopl2009
Other PublicationTRENDS IN CELL BIOLOGYRegeneration, repair and remembering identity: the three Rs of Hox gene expression2009
Other PublicationCELL STEM CELLHierarchical Maintenance of MLL Myeloid Leukemia Stem Cells Employs a Transcriptional Program2009
Other PublicationARTHRITIS AND RHEUMATISMMolecular Framework for Response to Imatinib Mesylate in Systemic Sclerosis2009
Other PublicationMOLECULAR CELLING4 Mediates Crosstalk between Histone H3 K4 Trimethylation2009
Other PublicationCELLSIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-kappa B-Dependent Gene Expression2009
Other PublicationANNUAL REVIEW OF BIOCHEMISTRYGenome-Wide Views of Chromatin Structure2009
Other PublicationPLOS ONEGlobal Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory2008
Other PublicationCELL CYCLEStemness, cancer and cancer stem cells2008
Other PublicationEUROPEAN JOURNAL OF CANCERCombining biological gene expression signatures in predicting outcome in breast cancer2008
Other PublicationSCIENCEDeletional tolerance mediated by extrathymic Aire-expressing cells2008
Other PublicationGENES & DEVELOPMENTControl of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD32008
Other PublicationJOURNAL OF CLINICAL INVESTIGATIONMechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire2008
Other PublicationCELL STEM CELLModule map of stem cell genes guides creation of epithelial cancer stem cells2008
Other PublicationJOURNAL OF INVESTIGATIVE DERMATOLOGYA systems biology approach to anatomic diversity of skin2008
Other PublicationNATURESIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin2008
Other PublicationCELL CYCLEReversal of aging by NF kappa B blockade2008
Other PublicationGENOME RESEARCHSystematic functional characterization of cis-regulatory motifs in human core promoters2008
Other PublicationGENES & DEVELOPMENTA dermal HOX transcriptional program regulates site-specific epidermal fate2008
Other PublicationCANCER RESEARCHCSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression2008
Other PublicationCANCER RESEARCHRevealing targeted therapy for human cancer by gene module maps2008
Other PublicationGENES & DEVELOPMENTMotif module map reveals enforcement of aging by continual NF-kappa B activity2007
Other PublicationNATUREA histone H3 lysine 27 demethylase regulates animal posterior development2007
Other PublicationNATURE MEDICINETurning skin into embryonic stem cells2007
Other PublicationCELLFunctional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs2007
Other PublicationNATURE BIOTECHNOLOGYDecoding global gene expression programs in liver cancer by noninvasive imaging2007
Other PublicationPLOS GENETICSA transcriptional program mediating entry into cellular quiescence2007
Other PublicationPLOS GENETICSGenome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs2007
Other PublicationJOURNAL OF INVESTIGATIVE DERMATOLOGYPatterning skin pigmentation via dickkopf2007
Other PublicationONCOGENEGSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN2007
Other PublicationJOURNAL OF EXPERIMENTAL MEDICINESpontaneous autoimmunity prevented by thymic expression of a single self-antigen2006
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OBone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer2006
Other PublicationPLOS GENETICSAnatomic demarcation by positional variation in fibroblast gene expression programs2006
Other PublicationCANCER RESEARCHMYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species2006
Other PublicationCELL CYCLEFrom description to causality - Mechanisms of gene expression signatures in cancer2006
Other PublicationNATURE GENETICSGenetic regulators of large-scale transcriptional signatures in cancer2006
Other PublicationSTEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLSMicroarray analysis of stem cells and differentiation2006
Other PublicationBREAST CANCER RESEARCHPredicting a local recurrence after breast-conserving therapy by gene expression profiling2006
Other PublicationJOURNAL OF INVESTIGATIVE DERMATOLOGYLearning more from microarrays: Insights from modules and networks2005
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ORobustness, scalability2005
Other PublicationPLoS biologyGene expression signature of fibroblast serum response predicts human cancer progression2004
Other PublicationARCHIVES OF DERMATOLOGYKinetics and specificity of Fas ligand induction in toxic epidermal necrolysis2004
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OEndothelial cell diversity revealed by global expression profiling2003
Other PublicationARCHIVES OF DERMATOLOGYEruptive xanthomas associated with olanzapine use2003
Other PublicationJOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGYMyelogenous leukemia cutis resembling stasis dermatitis2003
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OGenomewide view of gene silencing by small interfering RNAs2003
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ODiversity, topographic differentiation, and positional memory in human fibroblasts2002
Other PublicationMICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWSProteases for cell suicide: Functions and regulation of caspases2000
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES ODissecting Fas signaling with an altered-specificity death-domain mutant1999
Other PublicationSCIENCEActivation of apoptosis signal regulating kinase 1 (ASK1) by the adapter protein Daxx1998
Other PublicationSCIENCEEssential role of CED-4 oligomerization in CED-3 activation and apoptosis1998
Other PublicationMOLECULAR CELLAutoproteolytic activation of pro-caspases by oligomerization1998
Other PublicationCELLDaxx, a novel Fas-binding protein that activates JNK and apoptosis1997
Other PublicationNATUREASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL INACTIVATION OF CALCINEURIN1995
Other PublicationMOLECULAR AND CELLULAR BIOLOGYACTIVATION OF CLN1 AND CLN2 G(1) CYCLIN GENE-EXPRESSION BY BCK21995
Other PublicationPROTEIN SCIENCEACTIVE-SITE MUTANTS OF HUMAN CYCLOPHILIN1992
Other PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OCYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B1992
Other PublicationtureLandscape and variation of R secondary structure across the human transcriptome.2014
Other PublicationCELLLong Noncoding Rs: Cellular Address Codes in Development and Disease2013
Other PublicationTUREControl of somatic tissue differentiation by the long non-coding R TINCR2013
Other PublicationeLifeA mammalian pseudogene lncR at the interface of inflammation and anti-inflammatory therapeutics.2013
Other Publicationture methodsTransposition of tive chromatin for fast and sensitive epigenomic profiling of open chromatin2013
Other PublicationCELLAging, Rejuvetion, and Epigenetic Reprogramming: Resetting the Aging Clock2012
Other PublicationTUREA long noncoding R maintains active chromatin to coordite homeotic gene expression2011
Other Publicationture protocolsGenome-wide mapping of R structure using nuclease digestion and high-throughput sequencing.2013
Other PublicationCURRENT OPINION IN CELL BIOLOGYCytotopic localization by long noncoding Rs2013
Other PublicationCELLThe NeST Long ncR Controls Microbial Susceptibility2013
Other PublicationJOURL OF INVESTIGATIVE DERMATOLOGYRejuvetion of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment2013
Other PublicationGENOME RESEARCHSeqFold: Genome-scale reconstruction of R secondary structure2013
Other PublicationTURE CHEMICAL BIOLOGYR SHAPE alysis in living cells2013
Other PublicationTURE METHODSSystematic reconstruction of R functiol motifs with high-throughput microfluidics2012
Other PublicationBMC GENOMICSIdentification of proteins binding coding and non-coding human Rs using protein microarrays2012
Other PublicationMOLECULAR CELLGenome-wide Measurement of R Folding Energies2012
Other PublicationPLOS ONEDetection of Long Non-Coding R in Archival Tissue2012
Other PublicationSTEM CELLS AND DEVELOPMENTA Molecular Sigture for Purified Definitive Endoderm Guides Differentiation2012
Other PublicationCURRENT OPINION IN GENETICS & DEVELOPMENTActive chromatin and noncoding Rs: an intimate relationship2012
Other PublicationGENES & DEVELOPMENTSuppression of progenitor differentiation requires the long noncoding R ANCR2012
Other PublicationGENOME BIOLOGYTranscriptiol profiling of long non-coding Rs2012
Other PublicationANNUAL REVIEW OF BIOCHEMISTRY, VOL 81Genome Regulation by Long Noncoding Rs2012
Other PublicationJourl of visualized experiments : JoVEChromatin isolation by R purification (ChIRP).
Other PublicationMOLECULAR CELLGenomic Maps of Long Noncoding R Occupancy Reveal Principles of R-Chromatin Interactions2011
Other PublicationCELL STEM CELLDirect Lineage Conversion of Termilly Differentiated Hepatocytes to Functiol Neurons2011
Other PublicationMOLECULAR CELLMolecular Mechanisms of Long Noncoding Rs2011
Other PublicationJOURL OF CLINICAL INVESTIGATIONDisruption of PPAR gamma2011
Other PublicationTURE REVIEWS GENETICSUnderstanding the transcriptome through R structure2011
Other PublicationEMBO REPORTSCrystal structure of the N-termil region of human Ash2L shows a winged2011
Other PublicationTURE GENETICSExtensive and coordited transcription of noncoding Rs within cell-cycle promoters2011
Other PublicationTRENDS IN CELL BIOLOGYLong noncoding Rs and human disease2011
Other PublicationPLOS GENETICSDymic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptiol Networks2011
Other PublicationEPIGENETICSR templating the epigenome Long noncoding Rs as molecular scaffolds2011
Other PublicationCANCER RESEARCHLong Intergenic Noncoding Rs: New Links in Cancer Progression2011
Other PublicationCELL STEM CELLNoncoding R Landmarks of Pluripotency and Reprogramming2010
Other PublicationJOURL OF CELL BIOLOGYG1 arrest and differentiation can occur independently of Rb family function2010
Other PublicationTUREGenome-wide measurement of R secondary structure in yeast2010
Other PublicationR BIOLOGYLong noncoding R in genome regulation Prospects and mechanisms2010
Other PublicationCELL CYCLEHOTAIR Flight of noncoding Rs in cancer metastasis2010
Other PublicationSCIENCELong Noncoding R as Modular Scaffold of Histone Modification Complexes2010
Other PublicationTURELong non-coding R HOTAIR reprograms chromatin state to promote cancer metastasis2010
Other PublicationJOURL OF INVESTIGATIVE DERMATOLOGYA TGF beta-Responsive Gene Sigture Is Associated with a Subset of Diffuse Scleroderma with2010
Other PublicationGENES & DEVELOPMENTThe histone demethylase UTX ebles RB-dependent cell fate control2010
Other PublicationSCIENCEAtomic Demarcation of Cells: Genes to Patterns2009
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMIdentification, molecular characterization2009
Other PublicationEMBO REPORTSGene dates, parties and galas Symposium on Chromatin Dymics and Higher Order Organization2009
Other PublicationCELL STEM CELLHierarchical Maintence of MLL Myeloid Leukemia Stem Cells Employs a Transcriptiol Program Shared2009
Other PublicationEUROPEAN JOURL OF CANCERCombining biological gene expression sigtures in predicting outcome in breast cancer2008
Other PublicationSCIENCEDeletiol tolerance mediated by extrathymic Aire-expressing cells2008
Other PublicationJOURL OF CLINICAL INVESTIGATIONMechanisms of an autoimmunity syndrome in mice caused by a domint mutation in Aire2008
Other PublicationJOURL OF INVESTIGATIVE DERMATOLOGYA systems biology approach to atomic diversity of skin2008
Other PublicationTURESIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin2008
Other PublicationGENOME RESEARCHSystematic functiol characterization of cis-regulatory motifs in human core promoters2008
Other PublicationGENES & DEVELOPMENTA dermal HOX transcriptiol program regulates site-specific epidermal fate2008
Other PublicationCANCER RESEARCHCSN5 isopeptidase activity links COP9 siglosome activation to breast cancer progression2008
Other PublicationTUREA histone H3 lysine 27 demethylase regulates animal posterior development2007
Other PublicationTURE MEDICINETurning skin into embryonic stem cells2007
Other PublicationCELLFunctiol demarcation of active and silent chromatin domains in human HOX loci by Noncoding Rs2007
Other PublicationTURE BIOTECHNOLOGYDecoding global gene expression programs in liver cancer by noninvasive imaging2007
Other PublicationPLOS GENETICSA transcriptiol program mediating entry into cellular quiescence2007
Other PublicationPLOS GENETICSGenome-wide alysis of KAP1 binding suggests autoregulation of KRAB-ZNFs2007
Other PublicationJOURL OF INVESTIGATIVE DERMATOLOGYPatterning skin pigmentation via dickkopf2007
Other PublicationJOURL OF EXPERIMENTAL MEDICINESpontaneous autoimmunity prevented by thymic expression of a single self-antigen2006
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMBone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer2006
Other PublicationPLOS GENETICSAtomic demarcation by positiol variation in fibroblast gene expression programs2006
Other PublicationCANCER RESEARCHMYC can induce D breaks in vivo and in vitro independent of reactive oxygen species2006
Other PublicationCELL CYCLEFrom description to causality - Mechanisms of gene expression sigtures in cancer2006
Other PublicationTURE GENETICSGenetic regulators of large-scale transcriptiol sigtures in cancer2006
Other PublicationSTEM CELL TOOLS AND OTHER EXPERIMENTAL PROTOCOLSMicroarray alysis of stem cells and differentiation2006
Other PublicationJOURL OF INVESTIGATIVE DERMATOLOGYLearning more from microarrays: Insights from modules and networks2005
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMRobustness, scalability2005
Other PublicationPLoS biologyGene expression sigture of fibroblast serum response predicts human cancer progression2004
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMEndothelial cell diversity revealed by global expression profiling2003
Other PublicationJOURL OF THE AMERICAN ACADEMY OF DERMATOLOGYMyelogenous leukemia cutis resembling stasis dermatitis2003
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMGenomewide view of gene silencing by small interfering Rs2003
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMDiversity, topographic differentiation, and positiol memory in human fibroblasts2002
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMDissecting Fas sigling with an altered-specificity death-domain mutant1999
Other PublicationSCIENCEActivation of apoptosis sigl regulating kise 1 (ASK1) by the adapter protein Daxx1998
Other PublicationTUREASYMMETRIC RETRACTION OF GROWTH CONE FILOPODIA FOLLOWING FOCAL ICTIVATION OF CALCINEURIN1995
Other PublicationPROCEEDINGS OF THE TIOL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMCYCLOSPORINE-MEDIATED INHIBITION OF BOVINE CALCINEURIN BY CYCLOPHILIN-A AND CYCLOPHILIN-B1992

Practice & Hospital Affiliations

Howard Y. Chang, MD has not yet indicated the hospitals that he is affiliated with.

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Specialties

Languages Spoken
English
Medical Specialties
  • Internist

Accepts New Patients: Yes

Accepted Insurance

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