Woolf Laboratory
Address
3 Blackfan Circle F.M. Kirby Neurobiology CenterBoston, MA 02115
Boston, MA 02115
Summary
Our group is devoted to investigating the way in which the functional, chemical and structural plasticity of neurons contributes both to the normal function and the diseases of the nervous system. Major efforts are devoted to the study of pain, regeneration, inflammation and neurodegenerative diseases. Most of our work is concentrated on primary sensory and motor neurons and on the interaction of neurons and immune cells, using a multidisciplinary approach spanning stem cell, molecular and cell biology, electrophysiology, optogenetics, neuroanatomy, behavior and genome editing. We have established functional and comparative genomic strategies using expression profiling, bioinformatics and gain- and loss-of-function approaches to screen for and validate novel genes that contribute to neuronal plasticity and diverse disease phenotypes. We also use human stem cell derived neurons to explore physiology and pathophysiology. The group works closely with many academic groups, and the pharmaceutical industry, both to model disease and identify molecular targets for novel analgesics, axonal growth determinants, anti-inflammatory and neuroprotective agents.
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