The Ploegh Laboratory
Address
300 Longwood AvenueBoston, MA 02115
Much of the research in the Ploegh lab is in the fields of biochemistry and immunology, which started with a specific focus on unraveling the mechanisms by which MHC molecules interact with antigens inside a cell. Later, while at the Whitehead Institute, the Ploegh lab began using a technique called 'sortagging' to look at the pathways through which viruses are able to avoid detection by the immune system. Ploegh has been involved in further developing therapeutic roles for sortagging. Additionally, the Ploegh lab now focuses on utilizing 'nanobodies', derived from the antibodies of alpaca's. Much of the research currently done in the lab uses these nanobodies for fundamental research and therapeutic applications.