Lieberman Laboratory
Address
320 Longwood Avenue Enders BuildingBoston, MA 02115
Boston, MA 02115
Summary
The Lieberman lab studies innate and adaptive immune responses to infection and cancer as well as the molecular basis of killer cell-mediated cytotoxicity. They described the first caspase-independent programmed cell death pathway (activated by granzyme A) and made major contributions to understanding the function of killer cell pore-forming proteins. The lab identified novel mechanisms of mitochondrial and DNA damage and RNA degradation activated by killer lymphocytes. Other work contributed to understanding how cytotoxic T lymphocyte function is regulated, particularly in chronic infections. The lab developed a new model for how perforin delivers the cytolytic proteases (granzymes) into target cells by activating the plasma membrane repair response. The lab was the first to describe CD8 T cell exhaustion in humans, which is the basis for current checkpoint blockade therapies for treating cancer.
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