He Laboratory
Address
3 Blackfan Circle F.M. Kirby Neurobiology CenterBoston, MA 02115
Boston, MA 02115
Summary
The He Laboratory is primarily interested in understanding the molecular workings of Wnt/b-catenin signaling in normal development and human pathology. In the absence of a Wnt ligand, the Axin destruction complex phosphorylates b-catenin to be degraded, preventing b-catenin from reaching the nucleus. Canonical Wnt signaling is initiated by the binding of a Wnt protein to coreceptors Frizzled and Lrp5/6, which recruits the Axin destruction complex to the membrane and allows b-catenin to accumulate and enter the nucleus to alter gene expression.
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