Briscoe Laboratory
Address
320 Longwood Avenue Enders BuildingBoston, MA 02115
Boston, MA 02115
Summary
Research in the Briscoe Laboratory relates to all these issues with a focus on the intragraft microenvironment, and how it functions to both promote and inhibit chronic rejection. Our studies focus on three broad areas including: 1) how events within the intragraft microenvironment including leukocyte-endothelial cell interactions promote, sustain, or inhibit T cell activation and allorecognition; 2) discrete signals and molecular interactions in select populations of T cells that are integral to inflammation resolution; and 3) the application of these discoveries into the development of biomarkers and new therapeutics to transform clinical care and improve outcomes following transplantation. We are expanding our research effort into the area of inflammation resolution, and we are specifically interested in endogenous mechanisms and regulatory signaling networks of pro-resolution. Understanding these processes will allow us to develop new paradigms for anti-rejection therapeutics following transplantation.
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